QSAR Studies on Ant Malarial Activity of Diverse Set of Compounds for D6 Strain of P. falciparum

Abstract

Malaria spread by sporozoa of p.falciperum and is well known as an infectious lethal disease.Sometimes it causes death if the medicine is not given in time.Only a limited number of drugs can now prevent and cure malaria.For in vitro testing the clones D6 and NF54 of p. felciperum are most often used.These are resistant to present drugs like mefloquine.The data set based on the D6 strains consisting of 57 organic compounds was collected from different sources and their antimalarial activity is predicted by taking different parametric models.